Yes, if you place each video on a separate track and then use track motion to position each wherever you want on the screen. You can size and place them as you like. If you only want part of a video to show, use pan/crop first to crop the image.
You'll find some pre-built veg files dividing the screen by 2, 3, and 4 sections, plus one from G. Farino on the Sundance site that has 16 divisions. http://www.sundancemediagroup.com/help/kb