Assuming you were scanning a 50x37.5" image for your project (that would be quite some scanner), I would think you would first find the smallest area you wanted to zoom in on. Assuming the aspect ratio of that area was 3:4, you would want that area in your scanned image to be 720 pixels along the long edge. Assuming that that area is 6x8 inches on the 50x37.5" image, for example, you would want to scan the 50x37.5 image at 90 dpi (6" image becomes 720 pixels long). That should give you the minimum size full image while keeping maximum quality on the zoom in. I have no idea what your total image size would be, but it would be pretty $%@#& large.