This from Rodeo, one of the Handbrake developers:
"The nightly builds have 10-bit decoding support for H.264 (and DNxHD, FWIW).
I'll make some time to test the first one this weekend and report back. But it should be great news for those of us who are using DNxHD as an intermediate from Vegas to Handbrake. 10-bit 4:2:2 encoding is not yet available in HB, largely because there is little mainstream use for it yet.