TVPaint is preparing for this by doubling the resolution scale of their software. Wacom has to do the same. I don't see any difference in performance on our computers, but we are 2D animators and that must be different. 2D looks better anyway. Won't Sony have to double the Vegas software's resolution as well?
I think in this case the old fashioned way would mean stop motion puppetry. There are hundreds of indie 2D animated films made all over the world today on laptops and tablets (2D meaning computer assist hand drawn).