In v2 I could go to the end of project by pressing E. In v4 it doesn't work.
Looking in help one can see that E has to do the same as in v2.
Am I missing something?
Press the 'End' key to go to the end of the project. The 'Home' key will return to the beginning. The 'Page Up' and 'Page Down' keys will go to the next or previous grid line, and holding the 'Ctrl' key and pressing the left or right arrows will go to the previous or next marker.
To elaborate a bit as to why your keyboard shortcut disappeared: 'E' now cycles through showing/hiding plug-in ('E' is for envelope <g>). Shift+E cycles in the other direction.
'W' and 'E' are used in some other audio software so we followed suit until we had another use for these keys. Since there is duplicate behavior with other, more standard, keyboard commands and we're running out of keys we took the 'E' key for a new purpose.
Also, Home and End actually move the edit cursor to the beginning and end of the currently visible part of the time line. Ctrl+Home and Ctrl+End move you to the beginning and end of the project.