I haven't tried this myself but a lttle while ago someone mentioned a switch that turns on something like Show Unquantised Frames. I have to wonder why that isn't on by default.
The "Show Unquantized Frames" puts a red marker where the data doesn't end on a frame boundary; I presume this is a good thing to know and you fix it by just moving the clip end back to the previous frame.
The internal change I always tout is the "Snap Pixel Width", which reduces the magnetic stickiness of clips on the timeline. Default is 7, I much prefer 3.
Other than those two, I've left the hundreds of other settings as they are.