I still use an older, simpler version of Acronis True Image (TI) for backup (essentially an .ISO generator with its own file extension .tib) that came with some HD for the bloated commercial version has been buggy for me, so I abandoned upgrading and using it 3 years ago. I do not use any compression for IMO while it's OK for .zip files as email attachments and single files, folders, there are just too many interdependent and numerous parts/files in an OS. And thus, yes, it takes up more space in the backup drive, but I feel it's safer.
As far as TI is concerned, there are basically only three compression types - low, medium, high.
Am I being overly cautious? Do you use compression - and/or have you had problems with restores of compressed backups, .ISO, etc.?
~ Philip