If this is NewBlue's TP4, I've had issues too. However, I've had both responsive and crucial assistance from their Customer Support. Please get in touch with them.
Having started with Titler Pro 1 - and upgrading each time in hopes of the problems being fixed - I'm happy to report V4 is far better than its predecessors (I think I can claim that it's perfect). I've not had any problems with either install or runtime.
Wish I could say the same for Boris 10 - which had to go thru the usual song-and-dance of uninstalls and reinstalls.
No luck. I have a brand new system that Vegas has been running pretty smoothly on but New Blue Titler Pro 4 hard crashes it. Can't even get it to open. Using Nvidea 970 with latest drivers.