I noticed today that Adobe has officially released Lightroom 2, which includes a native 64 bit version for 64 bit operating systems. Guess this is the start of the next generation of apps.
I'm actually a Cakewalk Sonar user. But I'm working in 32-bit thanks to the fact that most 3rd-party plugins are still 32-bit. So, despite the fact that Cakewalk is ahead of the game with a great 64-bit DAW, other software developers are holding up the game. Of course, the nightmare that is Vista (64bit or not) has not encouraged rapid migration...