My main screen is 4K/50Hz with Win10 scaled at 175%. Everything on the desktop is tack sharp and comfortable icon / text size. Opening VP16 under those circumstances with render a slightly blurry image on icons and text. Same at 150% ('recommended').
Selecting program properties>compatibility> override High DPI scaling by [application] brings this back to usable sharpness, even though this makes the writing is quite a bit smaller than I'd like it to be.. but this seems (for me) the best option.
Other attempts would cause the main screen / preview to size 'a little bit funny'..: I like the preview to be fixed at 1080 which should end up using approx 1/4 of a 4K screen real estate which wasn't the case..